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Fertility: There are no data on the effects of ropinirole on human fertility. In female fertility studies in rats, effects were seen on implantation (see Non-clinical Information under Actions). No effects were seen on male fertility in rats.
Pregnancy: There are no adequate and well-controlled studies of ropinirole in pregnant women. Ropinirole concentrations may gradually increase during pregnancy (see Pharmacokinetics under Actions). Studies in animals have shown embryo-foetal toxicity (see Non-clinical Information under Actions). It is recommended that REQUIP PD 24 HOUR is not used during pregnancy unless the potential benefit to the patient outweighs the potential risk to the foetus.
Lactation: There are no data regarding the excretion of ropinirole in human milk. Ropinirole has been detected in rat milk (see Non-clinical Information under Actions). REQUIP PD 24 HOUR should not be used in nursing mothers as it may inhibit lactation.
